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RESEARCH PRODUCT
Scaffolds based on hyaluronan crosslinked with a polyaminoacid: Novel candidates for tissue engineering application
Gaetano GiammonaGiovanna PitarresiGennara CavallaroSilvia FarèFabio Salvatore Palumbosubject
Materials scienceCompressive StrengthPolymersBiomedical EngineeringBiomaterialshyaluronanb-polyaspartylhydrazidechemistry.chemical_compoundMiceTissue engineeringMolar ratioCell MovementMaterials TestingCell AdhesionAnimalsHyaluronic AcidCytotoxicityCell adhesionCells CulturedCarbodiimideTissue EngineeringTissue Scaffoldstissue engineering hyaluronic acid chemical crosslinking composite scaffold polyasparthylhydrazideMetals and AlloysCell migrationchemical crosslinkinghyaluronan; a; b-polyaspartylhydrazide; chemical crosslinking; composite scaffolds; tissue engineeringSynthetic polymerPorous scaffoldchemistryChemical engineeringaCeramics and Compositescomposite scaffoldsPeptidesBiomedical engineeringdescription
New porous scaffolds, with a suitable hydrolytic and enzymatic degradation, useful for tissue engineering applications have been obtained by a carbodiimide mediated reaction between hyaluronan (HA) and a synthetic polymer with a polyaminoacid structure such as α,β-polyaspartylhydrazide (PAHy). Scaffolds with a different molar ratio between PAHy repeating units and HA repeating units have been prepared and characterized from a chemical and physicochemical point of view. Tests of indirect and direct cytotoxicity, cell adhesion, and spreading on these biomaterials have been performed by using murine L929 fibroblasts. The new biomaterials showed a good cell compatibility and ability to allow cell migration into the scaffolds as well as spreading on their surface. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-01 |