6533b861fe1ef96bd12c4f5e

RESEARCH PRODUCT

1,2,4-Oxadiazole rearrangements involving an NNC side-chain sequence.

Nicolò VivonaAntonio Palumbo PiccionelloSilvestre BuscemiAndrea Pace

subject

chemistry.chemical_compoundchemistryStereochemistryOrganic ChemistrySide chainTriazoleoxadiazole triazole solvent-free reactions heterocyclic rearrangementOxadiazoleSettore CHIM/06 - Chimica OrganicaPhysical and Theoretical ChemistryBiochemistrySequence (medicine)

description

The thermal rearrangement of N-1,2,4-oxadiazol-3-yl-hydrazones into 1,2,4-triazole derivatives is reported. This represents the first example of a three-atom side-chain rearrangement involving an NNC sequence linked at the C(3) of the oxadiazole. The reactions carried out under solvent-free conditions produced good to high yields of the final products.

yearjournalcountryeditionlanguage
2009-08-28Organic letters
10.1021/ol901687nhttps://pubmed.ncbi.nlm.nih.gov/19708710