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RESEARCH PRODUCT
Residential greenness-related DNA methylation changes
Dirk KeidelDirk KeidelFlorian KronenbergThomas RotheMedea ImbodenMedea ImbodenLuc BurdetKees De HooghKees De HooghGianfranco LovisonGianfranco LovisonGianfranco LovisonDanielle VienneauDanielle VienneauDeborah JarvisDeborah JarvisJohn W. HollowayAyoung JeongIkenna C. EzeIkenna C. EzeNicole Probst-henschsubject
Pathway analysisAllergyPhysical activityStress copingHealth benefitsBiologySettore MED/01 - Statistica MedicaCohort StudiesEpigenomeAir PollutionEnvironmental healthEnrichment testHumansGE1-350EWASGeneral Environmental ScienceDNAMethylationGreenness DNA methylation EWAS Enrichment test Pathway analysis Allergy Physical activity Allostatic loadDNA MethylationAllostatic loadEnvironmental sciencesDifferentially methylated regionsGreennessDNA methylationSettore SECS-S/01 - StatisticaCohort studydescription
Abstract Background Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 |