6533b861fe1ef96bd12c4fb6

RESEARCH PRODUCT

Functional Significance of Microsatellite Markers

Natalia ParamonovaTatjana SjaksteNikolajs Sjakste

subject

Genetic MarkersGeneticsUntranslated regionbusiness.industryIntronPromoterExonsGeneral MedicineIntronsExonHumansFunctional significanceMicrosatelliteMedicineGenetic Predisposition to DiseasePromoter Regions Geneticbusiness3' Untranslated RegionsGeneMicrosatellite RepeatsGenetic association

description

The review summarizes literature data on the positive results of association studies between the length of microsatellite repeats and predisposition to pathologies. Actually, the data can be classified according to the localization of the microsatellite: in the gene promoter, in the part of exon 1 coding the signal sequence, in gene introns, in the coding areas of genes, and in 3'-untranslated regions. The functional significance of microsatellite length changes can be evaluated in many cases. The authors came up to the conclusion that further studies on microsatellite associations with diseases remain prospective as they reflect changes in the gene functional activity.

yearjournalcountryeditionlanguage
2014-05-27Medicina
https://doi.org/10.3390/medicina49120079