Epidemioloģiskās saiknes molekulārā noteikšana nozokomiālo infekciju gadījumā

6533b861fe1ef96bd12c52cd

RESEARCH PRODUCT

Epidemioloģiskās saiknes molekulārā noteikšana nozokomiālo infekciju gadījumā

Baiba Zandersone

subject

description

Latvijas slimnīcās pieaug rezistence pret antibakteriālajiem līdzekļiem un nozokomiālo infekciju skaits. Galvenais KONS - Staphylococcus epidermidis virulences faktors ir spēja veidot biofilmas jeb bioplēves. S. epidermidis noteikšanai visbiežāk lieto tādas molekulārās tipēšanas metodes kā PFGE, MLST un SCCmec tipēšanu. Darba mērķis ir izmēģināt un izvērtēt MLST genotipēšanas metodi S. epidermidis epidemioloģiskai izpētei Latvijā. Pētījuma rezultātā vesela cilvēka mikroflorā tika novērota klonu daudzveidība, tas pierāda S. epidermidis ģenētisko dažādību. Sešiem S.epidermidis celmiem no viena pacienta bez S.epidermidis infekcijas pazīmēm, bija raksturīgi trīs MLST varianti (ST tipi), kas mainījās, atradoties intensīvas terapijas nodaļā vairākas dienas. Viens S. epidermidis celms no hemokultūras tika noteikts kā MRSE ar jaunu sekvenču tipu ST 483. Atslēgvārdi:Staphylococcus epidermidis, nozokomiālās infekcijas, KONS, MLST.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/16573

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