6533b861fe1ef96bd12c5650
RESEARCH PRODUCT
false
subject
musculoskeletal diseases0301 basic medicinePathologymedicine.medical_specialtyPlatelet-derived growth factormacromolecular substancesBiologyExtracellular matrix03 medical and health scienceschemistry.chemical_compound0302 clinical medicineJoint capsulemedicine030222 orthopedicsMultidisciplinaryCell biology030104 developmental biologymedicine.anatomical_structurechemistrybiology.proteinContracturemedicine.symptomSignal transductionMyofibroblastPlatelet-derived growth factor receptorTransforming growth factordescription
Background Contractile myofibroblasts (MFs) accumulate in the joint capsules of patients suffering from posttraumatic joint stiffness. MF activation is controlled by a complex local network of growth factors and cytokines, ending in the increased production of extracellular matrix components followed by soft tissue contracture. Despite the tremendous growth of knowledge in this field, inconsistencies remain in practice and prevention.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-05 | PLOS ONE |