6533b861fe1ef96bd12c56ea
RESEARCH PRODUCT
3-(4-Fluorophenyl)-1-methyl-4-(4-pyridyl)quinolin-2(1H)-one
Dieter SchollmeyerKatrin KinkelStefan LauferChristian Peifersubject
Crystallography13c nmr spectroscopyHydrogen bondStereochemistryChemistryStackingGeneral Materials ScienceGeneral ChemistryCrystal structureCondensed Matter PhysicsProtein kinase Adescription
The title compound, C21H15FN2O, was synthesized in the course of our studies of p38 mitogen-activated protein kinase inhibitors. It has been investigated by 1H and 13C NMR spectroscopy and was proven by X-ray crystallographic analysis to be the N-methyl rather than the O-methyl isomer. In the crystal structure, a three-dimensional network is formed consisting of quinolinone aromatic stacking interactions and weak C—H⋯O and C—H⋯N hydrogen bonds.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-04-18 | Acta Crystallographica Section E Structure Reports Online |