6533b861fe1ef96bd12c5a96
RESEARCH PRODUCT
Angiogenesis-related prognosis in patients with oral squamous cell carcinoma-role of the VEGF +936 C/T polymorphism.
Peer W. KämmererBernhard FrerichJan LieseSasa KalkanBilal Al NawasKai FruthJürgen Briegersubject
CD31AdultMaleVascular Endothelial Growth Factor ACancer Researchmedicine.medical_specialtyPathologyAngiogenesisVEGF receptorsSingle-nucleotide polymorphismBiologyGastroenterologyPolymorphism Single NucleotideDisease-Free SurvivalPathology and Forensic MedicineInternal medicinemedicineSNPHumansAlleleAgedAged 80 and overNeovascularization PathologicSquamous Cell Carcinoma of Head and NeckNeoplasms Second PrimaryMiddle AgedPrognosisImmunohistochemistryStainingSurvival Ratestomatognathic diseasesOtorhinolaryngologyHead and Neck NeoplasmsLymphatic Metastasisbiology.proteinCarcinoma Squamous CellPeriodonticsFemaleMouth NeoplasmsOral SurgeryNeoplasm Recurrence LocalImmunostainingdescription
BACKGROUND: The aim of the study was the immunohistological assessment of VEGF-single nucleotide polymorphism (SNP)-related angiogenic activity in oral squamous cell carcinoma (OSCC) in correlation with prognosis. METHODS: Fifty OSCC samples were immunostained with CD31-antibodies. Mean microvessel density (MVD) and staining intensity were determined and associated with clinicopathological/prognostic features as well as with the VEGF +936C/T SNP. RESULTS: A significant higher MVD could be seen for T3 and T4 compared with T1 and T2, N > 0 vs. N0 as well as G3–G4 vs. G1–G2 OSCCs (all: P < 0.05). A higher MVD was also associated with increased and earlier rates of local relapses, more metastases, and a significant decreased overall as well as disease-free survival (all: P < 0.05). When comparing T1 and T2 samples with +936-T-allele with T 1&2 samples without this allele, staining intensity was significantly increased (P = 0.002). CONCLUSIONS: Angiogenesis influences local as well as distant growth of OSCCs with a significant correlation between prognostic parameters. The correlation between VEGF +936-T-allele and increased CD31 immunostain needs further confirmation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-09-12 | Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology |