Dimēriskas dCas9-FokI sistēmas izveidošana efektīvai zīdītāju šūnu genoma rekombinēšanai

6533b862fe1ef96bd12c5ca9

RESEARCH PRODUCT

Dimēriskas dCas9-FokI sistēmas izveidošana efektīvai zīdītāju šūnu genoma rekombinēšanai

subject

CRISPR/Cas sistēma gene editing Bioloģija genoma rekombinēšana dCas9-FokI sistēma

description

CRISPR/Cas9 sistēma nodrošina robustu un plaši pielietojamu genoma rekombinēšanas tehnoloģiju, kas paver iespēju zinātniekiem precīzi manipulēt ar specifickiem genoma elementiem, ko izmantot gēnu funkciju pētījumos bioloģijā un slimību attīstībā. Darba mērķis bija izveidot un optimizēt dCas9-FokI sistēmu, kas nodrošinātu stabilu un specifisku genoma rekombinēšanu cilvēka šūnās. Mēs piedāvājam alternatīvu tehnoloģiju, kas ir balstīta uz RNS vadītu dCas9-FokI sistēmu un piedāvā ievērojamu genoma rekombinēšanas potenciālu ar samazinātu nespecifiskās šķelšanas (off-targeting) efektu. Iegūtie dati liecina, ka šī izveidotā sistēma var tikt efektīvi izmantota genoma rekombinēšanai zīdītāju šūnās. Iegūtie rezultāti var kalpot kā priekšizpētes dati tālākiem pētījumiem, lai palielinātu dCas9-FokI sistēmas efektivitāti un daudzpusīgo pielietojumu. Darbs tika izstrādāts Dānijā, HEALTH Aarhus Universitātē, asoc.prof. Jacob Giehm Mikkelsen vadītajā laboratorijā Biomedicīnas departamentā laika posmā no 2014.gada februāra līdz 2014.gada jūnijam.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/28561

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