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RESEARCH PRODUCT

Preparation of a Series of “Ru(p-cymene)” Complexes with Different N-Heterocyclic Carbene Ligands for the Catalytic β-Alkylation of Secondary Alcohols and Dimerization of Phenylacetylene

Amparo PradesMónica VicianoMercedes SanaúEduardo Peris

subject

p-CymeneTransition metal carbene complexOrganic ChemistryCrystal structureAlkylationMedicinal chemistryCatalysisInorganic Chemistrychemistry.chemical_compoundchemistryPhenylacetyleneOrganic chemistryPhysical and Theoretical ChemistryCarbene

description

A series of five different “(p-cymene)Ru(NHC)” complexes (NHC = imidazolin-2-ylidene, imidazolin-4-ylidene, and pyrazolin-3-ylidene) have been obtained and fully characterized. The crystal structure of two of the new complexes has been determined by X-ray diffraction methods. All five complexes have been tested in the catalytic β-alkylation of secondary alcohols with primary alcohols and the dimerization of phenylacetylene, showing an excellent activity in both processes. A clear improvement on the catalytic activity of the complexes is observed when the more basic NHC ligands are used. The pyrazolylidene-Ru complex lies among the best catalysts for the β-alkylation of secondary alcohols reported to date.

yearjournalcountryeditionlanguage
2008-07-29Organometallics
https://doi.org/10.1021/om800377m