6533b862fe1ef96bd12c750f

RESEARCH PRODUCT

ChemInform Abstract: (S)-Proline Benzyl Ester as Chiral Auxiliary in Lewis Acid-Catalyzed Asymmetric Diels-Alder Reactions.

Herbert Waldmann

subject

chemistry.chemical_classificationchemistry.chemical_compoundChiral auxiliaryCyclopentadienechemistryDiels alderDiastereomerGeneral MedicineLewis acids and basesProline benzyl esterBridged compoundsMedicinal chemistryCatalysis

description

Asymmetric Diels-Alder reaction of cyclopentadiene (I) with (S)-proline benzyl ester (II) yields a mixture of the diastereomeric cycloadducts (R)-(III) and (S)-(IV).

https://doi.org/10.1002/chin.198925065