6533b863fe1ef96bd12c77cf

RESEARCH PRODUCT

Studies on the mechanism of PMN activation. I. By dextran sulfates.

J. MüllerE. M. LemmelP. AlföldyU. Botzenhardt

subject

ChemistryNeutrophilsPhagocytosisNitroblue TetrazoliumComplement Pathway Alternativechemical and pharmacologic phenomenaDextransHematologyGeneral MedicineComplement systemchemistry.chemical_compoundDegree of substitutionDextranBiochemistryPhagocytosisAlternative complement pathwayBiophysicsHumans

description

Evidence is presented that enhanced reduction of the dye nitroblue-tetrazolium (NBT) by polymorphonuclear leukocytes (PMN) which are stimulated by dextran sulfates (DS) is not exclusively due to the phagocytosis of particles formed by NBT and DS. Not only the size of phagocytizable particles but the degree of substitution determines the acceleration of NBT-reduction. A likely cause of this acceleration is the triggering of the alternative pathway of the complement activation.

yearjournalcountryeditionlanguage
1982-06-01Blut
10.1007/bf00319921https://pubmed.ncbi.nlm.nih.gov/6177366