6533b863fe1ef96bd12c7845
RESEARCH PRODUCT
Preparation and characterization of new hydrogels based on hyaluronic acid and α,β-polyaspartylhydrazide
Giuseppe TripodoGiovanna PitarresiGaetano GiammonaGennara CavallaroFabio Salvatore Palumbosubject
chemistry.chemical_classificationMaterials sciencePolymers and PlasticsHydrochlorideOrganic ChemistryGeneral Physics and AstronomyPolymerchemistry.chemical_compoundHydrolysischemistryDistilled waterHyaluronidaseHyaluronic acidSelf-healing hydrogelsPolymer chemistryMaterials ChemistrymedicineSwellingmedicine.symptomhyaluronic acid scaffoldsNuclear chemistrymedicine.drugdescription
Abstract Hyaluronic acid (HA) has been crosslinked with α,β-polyaspartylhydrazide (PAHy). The crosslinking reaction has been performed in acidic medium in the presence of various amounts of N-ethyl-N′-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDC). All obtained samples have been characterized by FT-IR analysis and swelling measurements in double distilled water that have confirmed the occurrence of a chemical linkage between two polymers and the affinity towards aqueous medium of HA–PAHy networks, respectively. In vitro degradation assays have been performed in simulated physiological conditions as well as in the presence of hyaluronidase. Experimental data evidenced that HA–PAHy samples undergo a poor chemical and a reduced enzymatic degradation unlike native HA.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-09-01 | European Polymer Journal |