Sirtuins and Aging: is there a Role for Resveratrol?

6533b863fe1ef96bd12c78cc

RESEARCH PRODUCT

Sirtuins and Aging: is there a Role for Resveratrol?

Caterina Carollo Alberto Firenze Gregorio Caimi

subject

Aging media_common.quotation_subject Human life Calorie restriction Longevity Resveratrol Biology Genomic Stability Cell biology chemistry.chemical_compound Physiological Aging Biochemistry chemistry Resveratrol Sirtuin biology.protein Sirtuins Resveratrol; Aging; Sirtuins Beneficial effects media_common

description

Prolonged human life duration is consequently associated with a higher incidence of chronic diseases. Aging is a very complex process in which genetic, environmental and cellular pathways are involved. Along with aging, longevity has been linked with Sirtuins. Sirtuin enzymes are a family of highly conserved protein deacetylases that have been linked with calorie restriction and aging by modulating energy metabolism, genomic stability and stress resistance. Aim of this brief review is to describe Sirtuins’ influence on the conditions that worsen the physiological aging. We will also report the beneficial effects of the polyphenol resveratrol on these molecules and the possible therapeutical perspectives.

year	journal	country	edition	language
2016-06-30

http://hdl.handle.net/10447/208028

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