6533b863fe1ef96bd12c78d1
RESEARCH PRODUCT
Herbicidally Active Derivatives of Aminomethylenebis-Phosphonic Acid-Mode of Action and Structure - Activity Relationship
Joanna KorfRoman GancarzGiuseppe ForlaniPiotr WieczorekHubert WojtasekJadwiga SołoduchoBogdan BoduszekBarbara LejczakChristophe TorreillesJoanna HafnerPaweł Kafarskisubject
chemistry.chemical_classificationamino acid biosynthesisbiologyStereochemistryOrganic Chemistry(N-pyridylamino)methylenebisphosphonatesDAHP synthaseBiochemistryInorganic Chemistrychemistry.chemical_compound(N-pyridylamino)methylenebisphosphonates; amino acid biosynthesis; inhibitorsEnzymechemistryBiosynthesisinhibitorsbiology.proteinAromatic amino acidsStructure–activity relationshipShikimate pathwayMode of actiondescription
Abstract: (N-pyridylamino)methylenebisphosphonates exhibit strong herbicidal activity which may be reversed by supplementation of the growth media with aromatic amino acids. They appeare to be the inhibitors of aromatic amino acids biosynthesis acting as inhibitors of DAHP synthase the first enzyme of shikimate pathway. Over 40 analogues of these acids were synthesized in order to determine the structure-activity relationship.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-01-01 | Phosphorus, Sulfur, and Silicon and the Related Elements |