6533b86cfe1ef96bd12c7ed9
RESEARCH PRODUCT
Polycondensed nitrogen heterocycles. Part 22. Pyrrolo[3,4-d]-1,2,3-triazines: A new ring system as potential antineoplastic agent
Girolamo CirrincioneGaetano DattoloAnna Maria AlmericoEnrico Aiellosubject
chemistry.chemical_compoundIntramolecular reactionNitrileBicyclic moleculeChemistryIntramolecular forceOrganic ChemistryOrganic chemistryAzo couplingAliphatic compoundRing (chemistry)Combinatorial chemistryCoupling reactiondescription
Diazotization of the 3-aminopyrrole-4-carboxamides 6a,b under different conditions directly led to the new ring system pyrrolo[3,4-d]-1,2,3-triazine in excellent yields through an intramolecular coupling reaction. In all the cases it was impossible to isolate the intermediate 3-diazopyrroles.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-11-01 | Journal of Heterocyclic Chemistry |