6533b86cfe1ef96bd12c833a
RESEARCH PRODUCT
Test and power considerations for multiple endpoint analyses using sequentially rejective graphical procedures
Willi MaurerGerhard HommelFrank BretzFrank Bretzsubject
Statistics and ProbabilityTest strategyEndpoint DeterminationEpidemiologyComputer scienceControl (management)Analysis of clinical trialsMachine learningcomputer.software_genresymbols.namesakeDrug TherapyComputer GraphicsConfidence IntervalsHumansMulticenter Studies as TopicRandomized Controlled Trials as Topicbusiness.industryVariety (cybernetics)Test (assessment)Clinical trialBonferroni correctionClinical Trials Phase III as TopicData Interpretation StatisticalMultiple comparisons problemsymbolsArtificial intelligencebusinessAlgorithmcomputerdescription
A variety of powerful test procedures are available for the analysis of clinical trials addressing multiple objectives, such as comparing several treatments with a control, assessing the benefit of a new drug for more than one endpoint, etc. However, some of these procedures have reached a level of complexity that makes it difficult to communicate the underlying test strategies to clinical teams. Graphical approaches have been proposed instead that facilitate the derivation and communication of Bonferroni-based closed test procedures. In this paper we give a coherent description of the methodology and illustrate it with a real clinical trial example. We further discuss suitable power measures for clinical trials with multiple primary and/or secondary objectives and use a generic example to illustrate our considerations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-12-07 | Statistics in Medicine |