Heterozigotiskas ģimenes hiperholesterinēmijas sastopamība starp Latvijas kardioloģijas centra pacientiem ar augstu holesterīna līmeni

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RESEARCH PRODUCT

Heterozigotiskas ģimenes hiperholesterinēmijas sastopamība starp Latvijas kardioloģijas centra pacientiem ar augstu holesterīna līmeni

Kārlis Ventiņš

subject

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Aptuveni 1/500 kaukazoīdu rases pārstāvjiem ir sastopama autosomāli dominanta pārmantota heterozigotiska ģimenes hiperholesterinēmija (ĢH). Mērķis: apzināt ĢH pacientu sastopamību Latvijas Kardioloģijas centrā starp pacientiem ar paaugstinātu kopējo holesterīnu (KH) un zema blīvuma lipoproteīna holesterīnu (ZBLH). Metode: pētījumā iekļauti pacienti ar KH ≥ 7 mmol/l vai ZBLH ≥ 5 mmol/l, anketēti, paņemts asins paraugs un pārbaudīta mutāciju esamība ZBL receptora un apoproteīna B gēnā. Izmantojot PVO un Nīderlandes ĢH diagnostiskos kritērijus, noteikta diagnozes ticamība. Secinājumi: lielākā daļa pacientu atbilst iespējamai un ticamai ĢH diagnozei. Nevienam no pacientiem netika atrasta kāda no 8 meklētajām mutācijām. Pacientiem ar KVS pirmās pakāpes radiniekiem (46,4%), ZBLH bija statistiski ticami augstāks (p=0,029. Augsts un ļoti augsts kardiovaskulārais (KV) risks ir 91,3% pacientu. Nepastāv ticama saistība starp KV risku un ĢH diagnostiskajiem kritērijiem.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/24369

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