6533b86cfe1ef96bd12c870e
RESEARCH PRODUCT
Photochemotherapeutic heterocyclic agents having antiproliferative and antineoplastic activity
F Dall'acquaA. SalvadorGirolamo CirrincionePaola Barrajasubject
phototoxicityantineoplasticangelicinphotochemotherapeuticdescription
The present invention concerns the synthesis of new analogs of angelicins, pyrrolo[3,2-h]quinoline, for the treatment of pathologie having hyperproliferative character including those having neoplastic nature. The treatment is based on the combined action of pyrrolo[3,2-h]quinolines and UV-A light, through a clinical approach defined as PUVA (psoralen-UVA light). The most important feature of these compounds is that they exert their remarkable phototoxicity without any DNA damage, which is the main origin of the side effects of the PUVA therapy
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-01 |