6533b86cfe1ef96bd12c8b3b

RESEARCH PRODUCT

One-pot, direct incorporation of [11C]CO2 into carbamates.

Sidney M. HillJoanna S. FowlerJoanna S. FowlerJoanna S. FowlerMichael J. SchuellerAchim T. ReibelJacob M. Hooker

subject

Isotopic labelingBridged Bicyclo CompoundsExtramuralChemistryPositron-Emission TomographyGeneral ChemistryCarbamatesCarbon RadioisotopesCarbon DioxideRadiopharmaceuticalsBridged Bicyclo Compounds HeterocyclicCatalysisNuclear chemistry

description

Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of (11)CO(2) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of (11)C-labeled carbamates at 75 degrees C within 10 minutes in radiochemical yields above 70% (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

yearjournalcountryeditionlanguage
2009-04-08Angewandte Chemie (International ed. in English)
10.1002/anie.200900112https://pubmed.ncbi.nlm.nih.gov/19554578