Differential effects of MDMA and cocaine on inhibitory avoidance and object recognition tests in rodents.

6533b86cfe1ef96bd12c8d1a

RESEARCH PRODUCT

Differential effects of MDMA and cocaine on inhibitory avoidance and object recognition tests in rodents.

María Asunción Aguilar Calpe José Enrique De La Rubia Ortí María Pilar García-pardo

subject

medicine.medical_specialty MDMA Cognitive Neuroscience media_common.quotation_subject N-Methyl-3 4-methylenedioxyamphetamine Ecstasy Investigación médica Ensayos clínicos Experimental and Cognitive Psychology Rodentia Public problem Inhibitory postsynaptic potential 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Cocaine Dopamine Uptake Inhibitors mental disorders medicine Avoidance Learning Animals Drogas Psychiatry media_common Memory Disorders Adrenergic Uptake Inhibitors Behavior Animal Addiction MDMA Cognition Recognition Psychology Inhibitory avoidance Abstinence Differential effects 030227 psychiatry Efectos fisiológicos Psychology Estupefaciente 030217 neurology & neurosurgery medicine.drug

description

Introduction Drug addiction continues being a major public problem faced by modern societies with different social, health and legal consequences for the consumers. Consumption of psychostimulants, like cocaine or MDMA (known as ecstasy) are highly prevalent and cognitive and memory impairments have been related with the abuse of these drugs. Aim The aim of this work was to review the most important data of the literature in the last 10 years about the effects of cocaine and MDMA on inhibitory avoidance and object recognition tests in rodents. Development: The object recognition and the inhibitory avoidance tests are popular procedures used to assess different types of memory. We compare the effects of cocaine and MDMA administration in these tests, taking in consideration different factors such as the period of life development of the animals (prenatal, adolescence and adult age), the presence of polydrug consumption or the role of environmental variables. Brain structures involved in the effects of cocaine and MDMA on memory are also described. Conclusions Cocaine and MDMA induced similar impairing effects on the object recognition test during critical periods of lifetime or after abstinence of prolonged consumption in adulthood. Deficits of inhibitory avoidance memory are observed only in adult rodents exposed to MDMA. Psychostimulant abuse is a potential factor to induce memory impairments and could facilitate the development of future neurodegenerative disorders. Sin financiación 3.244 JCR (2017) Q1, 14/78 Psychology, 11/51 Behavioral Sciences; Q2, 109/261 Neurosciences UEV

year	journal	country	edition	language
2017-12-01	Neurobiology of learning and memory

10.1016/j.nlm.2017.10.013 https://pubmed.ncbi.nlm.nih.gov/29081371