Inhibition of angiotensin converting enzyme in vitro by flavonoids, metformin and Vaccinium spp. berry pomace extracts

6533b86cfe1ef96bd12c8efd

RESEARCH PRODUCT

Inhibition of angiotensin converting enzyme in vitro by flavonoids, metformin and Vaccinium spp. berry pomace extracts

subject

metformīns Vaccinium spp. ogu izspiedu ekstrakti AKE Farmācija flavonoīdi inhibīcija

description

Pasaulē viena no galvenajām sabiedrības veselības problēmām ir arteriālā hipertensija. AKE inhibīcija tiek identificēta kā galvenais terapeitiskais mērķis augsta asinsspiediena kontrolē. Tomēr šobrīd pasaulē ir COVID-19 vīrusa uzliesmojums, smags akūts respiratorais vīruss. AKE2 tika identificēts kā SARS (smags akūts respiratorais sindroms) koronavīrusa receptors. AKE2 ir arī koronovīrusa COVID-19 receptors. AKE2 pētījumiem tiek pievērsta liela uzmanība visā pasaulē. Pētījuma mērķis bija noteikt dažādu flavonoīdu, metformīna un Vaccinium ģints ogu melleņu, dzērveņu un brūkleņu izspiedu ekstraktu spēju inhibēt AKE in vitro testos, salīdzināt flavonoīdu AKE1 un AKE2 inhibīcijas efektus ar atbilstošiem enzīmu inhibitoriem un noskaidrot, vai vielām ir selektīvas īpašības. Iegūtie rezultāti liecina par flavonoīdu (rutīns, kvercetīns, florizīns, cianidīns) un Vaccinium spp. ogu izspiedu ekstraktu (meža melleņu, purva dzērveņu un brūkleņu ekstrakti) spēju inhibēt gan AKE1, gan AKE2.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54658

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