6533b86dfe1ef96bd12c941d
RESEARCH PRODUCT
Sponges (Porifera) Molecular Model Systems to Study Cellular Differentiation in Metazoa
Cristiano C. CoutinhoClaudia KoziolC. WagnerRadovan BorojevicRenate SteffenW. E. G. Müllersubject
Molecular modelEvolutionary biologyPhylumCellular differentiationGene duplicationAlternative splicingBiologyExon shufflingGenedescription
Evolution is a gradual process whereby primarily new genes are formed either by gene duplication (Ohno 1970) or exon shuffling (Gilbert 1978). New proteins can also be produced by overlapping genes, alternative splicing or gene sharing (Li and Graur 1991). These facts imply that (1) proteins found in a given phylum contain elements or modules which are present already in ancestral protein(s) of members of phylogenetically older phyla and (2) that new combinations of such modules create proteins that possess new functions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-01-01 |