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RESEARCH PRODUCT
How to Improve the Uterotomy Healing
Peter VaupelKarlheinz SchlengerMichael HöckelRenate SchwabRenate Frischmann-bergersubject
Pathologymedicine.medical_specialtybiologyBiologic responsebusiness.industryFibrin matrixFibrinAnesthesiabiology.proteinmedicineSurgeryTumor necrosis factor alphaCesarean deliveryWound healingbusinessTumor necrosis factor αWound hemorrhagedescription
Abstract Suboptimal uterotomy healing following cesarean delivery or metroplastic operations may lead to considerable complications. New insights in the biology of wound healing and the availability of a variety of biologic response modifiers open the possibility to modulate the process of wound healing in order to gain clinical benefits. Can uterotomy healing be improved by local application of biosubstances? We developed an uterotomy model in the rat and measured the bursting pressure at defined times postwounding as a functional parameter of wound healing. In addition, the healing process was assessed by serial light microscopic histology. Uterotomy healing was investigated in the presence of fibrin alone or with fibrin containing tumor necrosis factor-α (TNF-α-fibrin) compared to controls. The fibrin matrix incorporated into rat uterotomies reduced wound hemorrhage and led to a 45% increase of early (Day 3) bursting pressure (not significant). With 20 μg TNF-%alpha; in the fibrin matrix, Day 3 bursting pressure was elevated by more than 100% (P
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-03-01 | Journal of Surgical Research |