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RESEARCH PRODUCT

Vascular Risk Factors in Mild Cognitive Impairment Subtypes. Findings from the ReGAl Project.

E. MarianiR. MonasteroS. ErcolaniM. CaputoF. MangialascheF. T. FelizianiD. F. VitaleU. SeninP. Mecocci For The Regal Study Group

subject

MaleBrainNeuropsychological TestsMagnetic Resonance ImagingRisk AssessmentSeverity of Illness IndexIschemic Attack TransientRisk FactorsSurveys and QuestionnairesCognitive impairment Mild cognitive impairment subtypes Vascular risk factors White-matter lesionsActivities of Daily LivingPrevalenceHumansFemaleSettore MED/26 - NeurologiaAtrophyCognition DisordersAged

description

Abstract Background and Aim: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. Methods: Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. Results: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke. Conclusion: Our findings suggest that snmMCI may be considered a vascular cognitive disorder.

yearjournalcountryeditionlanguage
2007-11-03
http://hdl.handle.net/11391/153993