Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis.

6533b86dfe1ef96bd12ca005

RESEARCH PRODUCT

Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis.

Ashok K. Chaturvedi Anna L. Lazzell Stephen P. Saville Carlos Monteagudo Jose L. Lopez-ribot

subject

Microbiology (medical)Neuregulin-1 T-Lymphocytes Clinical Biochemistry Immunology Biology Vaccines Attenuated Microbiology Mice Immunity Candida albicans Immunology and Allergy Animals Candida albicans Fungal vaccine Vaccines Synthetic Attenuated vaccine Strain (biology)Candidiasis biochemical phenomena metabolism and nutrition Disseminated Candidiasis biology.organism_classification Vaccine Research Virology Survival Analysis Vaccination Immunization Fungal Vaccines

description

ABSTRACT We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.

year	journal	country	edition	language
2009-01-16	Clinical and vaccine immunology : CVI

10.1128/cvi.00480-08 https://pubmed.ncbi.nlm.nih.gov/19144791

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