Uz alfavīrusu rekombinanto replikonu pamata izveidotā HCV prototipa vakcīna

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Uz alfavīrusu rekombinanto replikonu pamata izveidotā HCV prototipa vakcīna

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DARBA ANOTĀCIJA Promocijas darba mērķis ir jauna tipa anti-HCV vakcīnu kandidātu izveidošana, pamatojoties uz vispārēju koncepciju, ka viens vai vairāki HCV strukturālie gēni tiek inkorporēti vīrusa – nesēja (mūsu gadījumā, SFV un Sindbis vīrusi) genomā, nodrošinot imunogēno struktūru amplifikāciju un ekspresēšanu. Šī sistēma tās augstā ekspresijas līmeņa, plašā saimniekšūnu spektra un citoplazmatiskās replikācijas dēļ nodrošina unikālu iespēju šūnu kultūrā, izmantojot rekombinantos alfavīrusus, kuros ievadīti HCV gēni, pētīt HCV dzīves ciklu un bioloģiju un izmantot rekombinantos vīrusus kā jauna tipa efektīvas vakcīnas.

year	journal	country	edition	language
2009-01-01

https://dspace.lu.lv/dspace/handle/7/3627

PEPhysical Sciences and Engineering
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