6533b86dfe1ef96bd12ca8b4

RESEARCH PRODUCT

Solvent Control in Electro-Organic Synthesis

Siegfried R. WaldvogelLara Schulz

subject

ElectrolysisKolbe electrolysis010405 organic chemistryChemistryOrganic Chemistry010402 general chemistryElectrosynthesis01 natural sciencesCombinatorial chemistryCoupling reactionElectrochemical fluorination0104 chemical scienceslaw.inventionSolventchemistry.chemical_compoundlawOrganic synthesisSolvent effects

description

Exploiting the solvent control within electro-organic conversions is a far underestimated parameter in prep-scale electrolysis. The beneficial application in several transformations is outlined and in particular discussed for the dehydrogenative coupling of arenes and heteroarenes. This simple electrolytic strategy in fluorinated solvents allows the modulation of the substrate’s nucleophilicity and the stabilization of the intermediates as well as of the final product from over-oxidation.1 Introduction2 Solvent Effects in Kolbe Electrolysis and Anodic Fluorination3 Unique Solvent Effects of 1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP)4 Anodic Dehydrogenative Coupling Reactions with Use of HFIP as the Solvent5 Conclusion

yearjournalcountryeditionlanguage
2018-12-13Synlett
https://doi.org/10.1055/s-0037-1610303