6533b86dfe1ef96bd12ca8c2

RESEARCH PRODUCT

ChemInform Abstract: Enantioselective Mannich Reaction of β-Keto Esters with Aromatic and Aliphatic Imines Using a Cooperatively Assisted Bifunctional Catalyst.

Antti J. NeuvonenPetri M. Pihko

subject

ChemistryOrganocatalysisEnantioselective synthesisDiastereomerOrganic chemistryGeneral MedicineMannich reactionBifunctional catalyst

description

The title reaction tolerates aliphatic and aromatic substituents on both reaction partners, affording products (III) as a mixture of inseparable diastereomers with low or without any diastereoselectivity.

https://doi.org/10.1002/chin.201513025