6533b86dfe1ef96bd12caa45
RESEARCH PRODUCT
Alloreactive and H-2-restricted Lyt 23 cytotoxic T lymphocytes derive from a common pool of antecedent Lyt 123 precursors.
Martin RöllinghoffHermann WagnerConny HardtKlaus PfizenmaierJ Kleinsubject
Cytotoxicity ImmunologicIsoantigensCellular differentiationT-LymphocytesImmunologychemical and pharmacologic phenomenaMice Inbred StrainsThymus GlandBiologyMiceMediatorH-2 AntigensImmunology and AllergyCytotoxic T cellAnimalsEffectorImmune SeraH-2 Antigenshemic and immune systemsCell DifferentiationArticlesPhenotypeCell biologyCytolysisCTL*PhenotypeReceptors MitogenImmunologydescription
If the collaborative requirement of Lyt 1 T helper cells is bypassed by the Lyt 1 T cell-derived mediator of T help, termed Il-2, upon antigenic stimulation, PNA+ Lyt 123 thymocytes differentiate into either alloreactive or H-2-restricted PNA- Lyt 23 cytotoxic effector cells. Along the differentiation pathway from Lyt 123 leads to 23 effector cells, cytolytic activity is carried out by T cells that still express the Lyt 123 phenotype. The data establish that Lyt 23 CTL are produced by differentiation from antecedent Lyt 123 cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-11-01 | The Journal of experimental medicine |