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RESEARCH PRODUCT

The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers

Ana BenitoMarta Rodríguez-ariasJosé M. TomásGonzalo HaroIsis Gil-miravetCésar Mateu

subject

Geneticsbusiness.industryGeneral NeuroscienceAddictionmedia_common.quotation_subjectGenetic counselingMAOBcocaineopioidsNeurosciences. Biological psychiatry. NeuropsychiatrySerotonergicArticlepolymorphismVariable number tandem repeatGenetic markerPharmacogenomicsmental disordersMedicinegeneticsMonoamine oxidase BOpiatepolydrug usebusinessRC321-571media_common

description

Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) receptor 1B and 2C (HTR1B 21 and HTR2C) pathway genes was performed in a sample of 302 polyconsumers. Our genetic association analysis revealed a significant association between a 184 base pair (bp) VNTR polymorphism in the MAOB gene and addiction to cocaine and opiates. This work highlights new genetic marker associations in cocaine and opiate polyconsumer addictions. These data help to clarify and quantify the complex role of genetics in addictive disorders, as well as their future contribution to the prevention (genetic counselling), diagnosis (genetic diagnosis of vulnerability), and treatment (pharmacogenomics) of these disorders. This research was funded by Centro Superior de Investigación en Salud Pública (CSISP), Spain (grant number CS2003-05-05); Valencian Reginal Government Department of Health, Spain (grant number T4591000); and Research Foundation of the Hospital Provincial de Castellón (Ref. CAF 15-049 and 21-026).

yearjournalcountryeditionlanguage
2021-09-24
10.3390/brainsci11101265