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RESEARCH PRODUCT

CENTENARIANS TRANSCRIPTOME IS UNIQUE AND REVEALS A ROLE OF BCL-XL IN SUCCESSFUL AGING

Consuelo BorrásC. MasJuan R. ViñaMarta Inglés

subject

0301 basic medicineTranscriptomeAbstracts03 medical and health sciences030104 developmental biologyHealth (social science)Successful agingbiology.proteinBcl-xLComputational biologyBiologyLife-span and Life-course StudiesHealth Professions (miscellaneous)

description

Centenarians not only enjoy an extraordinary aging, but also show a compression of morbidity. We identified 1721 mRNAs differentially expressed by PMBCs from centenarians when compared with septuagenarians and young people. Sub-network analysis led us to identify Bcl-xL as an important gene up-regulated in centenarians. We found that centenarians display lower plasma cytochrome C levels, higher mitochondrial membrane potential and also less cellular damage accumulation. Immune function is significantly impaired in septuagenarians compared with young people whereas centenarians maintain it. To further ascertain the functional role of Bcl-xL in cellular aging, we found in transduced lymphocytes from septuagenarians with Bcl-xL a reduction in senescent-related markers. Finally, C. elegans bearing a gain of function mutation in the BcL-xL ortholog ced-9 showed a significant increase in mean and maximal life span. These results show that mRNA expression in centenarians is unique and reveals that Bcl-xL plays an important role in successful aging.

yearjournalcountryeditionlanguage
2017-06-30Innovation in Aging
https://doi.org/10.1093/geroni/igx004.3090