Metformīna ietekme uz neiroģenēzi sporādiskas Alcheimera slimības žurku modelī

6533b86efe1ef96bd12cae49

RESEARCH PRODUCT

Metformīna ietekme uz neiroģenēzi sporādiskas Alcheimera slimības žurku modelī

subject

Streptozocīns Alcheimera slimība Metformīns Farmācija Neiroģenēze Neironu dzīvotspēja

description

Alcheimera slimība (AD) ir visbiežākais demences izraisītājs pasaulē, taču joprojām nav pieejama efektīva terapija, kas šo slimību ārstētu (Graham et al., 2017). Balstoties uz cukura diabēta un sporādiskas AD patoloģisko mehānismu līdzībām, AD sauc par 3. tipa diabētu (Steen et al., 2005), tāpēc pretdiabēta vielām saskatāms potenciāls AD apturēšanā. Šajā darbā pārbaudījām pretdiabēta medikamenta metformīna ietekmi uz neironu dzīvotspēju un neiroģenēzi veselu un streptozocīna inducētas sporādiskas AD tipa modeļa žurku smadzenēs. Iegūtie dati liecina, ka metformīns (75 mg/kg un 100 mg/kg) uzlabo neironu dzīvotspēju un saglabā neiroģenēzes procesus sporādiska AD tipa modeļa žurku smadzeņu garozā un hipokampā. Paliek nezināmi šo procesu pamatā iesaistītie šūnas signālceļi.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54687

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