6533b86efe1ef96bd12cb27a

RESEARCH PRODUCT

Carbohydrates as chiral templates: Diastereoselective Ugi synthesis of (S)-amino acids using O-acylated D-arabinopyranosylamine as the auxiliary

Wilfried SagerHorst KunzWaldemar Pfrengle

subject

chemistry.chemical_classificationGlycosylamineChemistryFormic acidStereochemistryIsocyanideOrganic ChemistryPhenylalanineBiochemistryAldehydeAmino acidchemistry.chemical_compoundDrug DiscoveryOrganic chemistryUgi reactionAliphatic compound

description

Abstract Enantiomerically pure (S)-amino acids are synthesized via a highly diastereoselective Ugi reaction using 2,3,4-tri-O-pivaloyl-α-D-arabinopyranosylamine as the chiral template.

https://doi.org/10.1016/s0040-4039(00)99334-1