6533b86efe1ef96bd12cb2a0
RESEARCH PRODUCT
An efficient method for the preparation of antitumoral α-keto-imines benzyldihydroisoquinolines by selective benzylic oxidation with C/Pd in acetonitrile
Immaculada AndreuDiego CortesAlmudena BermejoAlain PierreDaniel Henri CaignardGhanem AtassiPierre RenardNuria Cabedosubject
chemistry.chemical_compoundchemistryCell cultureOrganic ChemistryDrug DiscoveryImineLeukemia L1210AcetonitrileBiochemistryMedicinal chemistryIn vitrodescription
A series of potent antitumor α-keto-imine BDHIQ derivatives were synthesized and assayed in vitro against L1210 leukemia cell line. A new and easy method for the direct formation of α-keto-imine from imine BDHIQ's was performed with 10% C/Pd in acetonitrile.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-01-01 | Tetrahedron Letters |