6533b86efe1ef96bd12cb2b3

RESEARCH PRODUCT

ChemInform Abstract: Base-Dependent Stereodivergent Intramolecular Aza-Michael Reaction: Asymmetric Synthesis of 1,3-Disubstituted Isoindolines.

Miguel A. MaestroPablo BarrioSantos FusteroRuben LazaroNatalia MateuLidia HerreraElsa Rodríguez

subject

ChemistryStereochemistryIntramolecular forceEnantioselective synthesisMichael reactionDiastereomerGeneral MedicineBase (exponentiation)

description

For the reaction of the compounds (I) the careful choice of the base allows the exclusive formation of either cis or trans diastereoisomer with the exception of the trihalogenates (Ie) and (If), which afford the cis-products regardless of the base used.

yearjournalcountryeditionlanguage
2014-01-02ChemInform
https://doi.org/10.1002/chin.201403116