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RESEARCH PRODUCT
Vitamin E transport, membrane incorporation and cell metabolism: Is α-tocopherol in lipid rafts an oar in the lifeboat?
Dominique NéelDominique NéelStéphanie Lemaire-ewingLaurent LagrostLaurent LagrostCatherine DesrumauxCatherine Desrumauxsubject
Cell deathAntioxidant[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition[SDV]Life Sciences [q-bio]medicine.medical_treatmentalpha-TocopherolSignal transductionBiologyAntioxidants03 medical and health scienceschemistry.chemical_compoundMembrane Microdomains0302 clinical medicineATP Binding Cassette Transporter Subfamily B Member 3medicineHumansVitamin ETocopherolATP Binding Cassette Transporter Subfamily B Member 2Protein PrecursorsLipid bilayerLipid raftLDL-Receptor Related Proteins030304 developmental biology0303 health sciencesTocopherolVitamin ECell MembraneBiological TransportBiological membraneLipid metabolismPeptide FragmentsCell biology[SDV] Life Sciences [q-bio]Lipid raftIntestinal AbsorptionLiverReceptors LDLBiochemistrychemistryATP-Binding Cassette Transporterslipids (amino acids peptides and proteins)Antioxidantalpha-Tocopherol[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition030217 neurology & neurosurgeryFood ScienceBiotechnologydescription
International audience; Vitamin E is composed of closely related compounds, including tocopherols and tocotrienols. Studies of the last decade provide strong support for a specific role of alpha-tocopherol in cell signalling and the regulation of gene expression. It produces significant effects on inflammation, cell proliferation and apoptosis that are not shared by other vitamin E isomers with similar antioxidant properties. The different behaviours of vitamin E isomers might relate, at least in part, to the specific effects they exert at the plasma membrane. alpha-Tocopherol is not randomly distributed throughout the phospholipid bilayer of biological membranes, and as compared with other isomers, it shows a propensity to associate with lipid rafts. Distinct aspects of vitamin E transport and metabolism is discussed with emphasis on the interaction between alpha-tocopherol and lipid rafts and the consequences of these interactions on cell metabolism.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-01 | Molecular Nutrition & Food Research |