6533b86efe1ef96bd12cbc9b
RESEARCH PRODUCT
The Significance of Low O2-Tensi0ns in the Brain Cortex for Occurrence of Metabolic Alterations under Critical Flow Conditions
J. GroteK. ZimmerR. Schubertsubject
chemistry.chemical_compoundmedicine.medical_specialtyEndocrinologychemistryTissue oxygen tensionArterial oxygen tensionInternal medicinemedicineBrain cortexNeuronal metabolismNAD+ kinasePhosphateNeurosciencedescription
A reduction in the 02 supply to the brain cortex leads to O2 deficiency and curtailment of neuronal metabolism and function as soon as a minimal cellular O2 tension of 0.1 – 1 mmHG (13 – 133 Pa) can no longer be maintained (Chance et al., 1964; Grote 1967). The hypoxia-induced metabolic alterations are characterized by decreased tissue levels of the energy-rich phosphate compounds PCr and ATP. In addition, elevated concentrations of lactate, pyruvate and NADH and an increase in the lactate/pyruvate ratio and in the NADH/NAD+ ratio are to be expected (Duffy et al., 1972; Granholm and Siesjo 1969; Granholm et al., 1969; Granholm and Siesjo 1971; Grote 1978; Grote and Schubert 1982; Norberg and Siesjo 1975; Norberg et al., 1975; Opitz and Schneider 1950; Schmahl et al., 1966).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1985-01-01 |