6533b86efe1ef96bd12cbd4d
RESEARCH PRODUCT
Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion
John G. HardyAndré PfaffAxel H. E. MüllerThomas ScheibelAldo Leal-egañasubject
chemistry.chemical_classificationMaterials sciencePolymers and PlasticsBiocompatibilityPolymer scienceGlycopolymerfungitechnology industry and agricultureBiomaterialBioengineeringNanotechnologymacromolecular substancesPolymerequipment and suppliesBiomaterialschemistry.chemical_compoundSILKchemistryMaterials ChemistrySurface modificationSpider silkCell adhesionBiotechnologydescription
Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-04-02 | Macromolecular Bioscience |