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RESEARCH PRODUCT
Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives
Gianluca ScaliaBipin ChaurasiaSalvatore MarroneSilvana TumbioloCesare GagliardoFrancesca GrazianoLuigi BasileFederico MidiriCarlo GulìGiuseppe Roberto GiammalvaRosario MaugeriKaan YağmurluFederica PaoliniLudovico La GruttaDomenico Gerardo IacopinoMaria Angela PinoRosa Maria GerardiDomenico MessinaGiuseppe Emmanuele Umanasubject
OpinionComputer scienceNeurodegenerative diseaseFocused ultrasoundlcsh:RC321-57103 medical and health sciences0302 clinical medicineneurodegenerative diseaseslcsh:Neurosciences. Biological psychiatry. Neuropsychiatry030304 developmental biologyBlood-brain barriertcMRgFUSLIFU0303 health sciencesEpilepsySettore MED/27 - NeurochirurgiaGeneral NeuroscienceSettore MED/37 - NeuroradiologiaPsychiatric disorderHIFUpsychiatric disordersfocused ultrasoundSettore MED/26 - NeurologiaSettore MED/36 - Diagnostica Per Immagini E RadioterapiaNeuroscienceneuro-oncology030217 neurology & neurosurgerydescription
Transcranial MR-guided Focused ultrasound (tcMRgFUS) is a surgical procedure that adopts focused ultrasounds beam towards a specific therapeutic target through the intact skull. The convergence of focused ultrasound beams onto the target produces tissue effects through released energy. Regarding neurosurgical applications, tcMRgFUS has been successfully adopted as a non-invasive procedure for ablative purposes such as thalamotomy, pallidotomy, and subthalamotomy for movement disorders. Several studies confirmed the effectiveness of tcMRgFUS in the treatment of several neurological conditions, ranging from motor disorders to psychiatric disorders. Moreover, using low-frequencies tcMRgFUS systems temporarily disrupts the blood–brain barrier, making this procedure suitable in neuro-oncology and neurodegenerative disease for controlled drug delivery. Nowadays, tcMRgFUS represents one of the most promising and fascinating technologies in neuroscience. Since it is an emerging technology, tcMRgFUS is still the subject of countless disparate studies, even if its effectiveness has been already proven in many experimental and therapeutic fields. Therefore, although many studies have been carried out, many others are still needed to increase the degree of knowledge of the innumerable potentials of tcMRgFUS and thus expand the future fields of application of this technology.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 | Brain Sciences |