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RESEARCH PRODUCT
Electrochemical Installation of CFH 2 −, CF 2 H−, CF 3 −, and Perfluoroalkyl Groups into Small Organic Molecules
Siegfried R. WaldvogelMárcio W. PaixãoAndreas P. HäringJosé A C DelgadoVitor A. FernandesCamila M. Kisukurisubject
chemistry.chemical_classification010405 organic chemistryTrifluoromethylationGeneral Chemical EngineeringAnodic oxidationGeneral Chemistry010402 general chemistryElectrochemistryElectrosynthesis01 natural sciencesBiochemistryCombinatorial chemistry0104 chemical sciencesOrganic moleculeschemistryMaterials ChemistryAlkyldescription
Electrosynthesis can be considered a powerful and sustainable methodology for the synthesis of small organic molecules. Due to its intrinsic ability to generate highly reactive species under mild conditions by anodic oxidation or cathodic reduction, electrosynthesis is particularly interesting for otherwise challenging transformations. One such challenge is the installation of fluorinated alkyl groups, which has gained significant attention in medicinal chemistry and material science due to their unique physicochemical features. Unsurprisingly, several electrochemical fluoroalkylation methods have been established. In this review, we survey recent developments and established methods in the field of electrochemical mono-, di-, and trifluoromethylation, and perfluoroalkylation of small organic molecules.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-06-21 | The Chemical Record |