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RESEARCH PRODUCT
Synthesis of Highly Fluorinated 2,2′-Biphenols and 2,2′-Bisanisoles
Robert FranckeGregor SchnakenburgSiegfried R. Waldvogelsubject
Coupling (electronics)ChemistryOrganic ChemistryPhysical and Theoretical ChemistryBiochemistryCombinatorial chemistrydescription
Multiply fluorine-substituted iodo anisoles are efficiently coupled in an Ullmann-type reaction to provide the corresponding bisanisoles. The coupling is selective and even tolerates bromo moieties. Subsequent deprotection of hydroxy groups gives access to highly fluorinated biphenols.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-08-30 | Organic Letters |