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subject

0301 basic medicine Immunology B cell biology breakpoint cluster region Biology Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine biology.protein Immunology and Allergy Secretion Antibody Cellular compartment 030215 immunology

description

The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and TFH cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.

year	journal	country	edition	language
2018-10-26	European Journal of Immunology

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