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RESEARCH PRODUCT
Tight Junctions as a Key for Pathogens Invasion in Intestinal Epithelial Cells
Tracy ParadisHervé BègueLouise BasmaciyanFrédéric DalleFabienne Bonsubject
0301 basic medicineCell Membrane Permeabilitytight junction030106 microbiologyReviewBiologyInfectionsCatalysisTight JunctionsInorganic Chemistrylcsh:Chemistry03 medical and health sciencesIntestinal mucosaAnimalsHumansPhysical and Theoretical ChemistryIntestinal MucosamicroorganismsMolecular Biologylcsh:QH301-705.5SpectroscopyGut barrierTight junctionBacteriagut barrierOrganic ChemistryEpithelial CellspathogensGeneral Medicinesignaling pathwaysComputer Science ApplicationsCell biologyIntestinal Diseases030104 developmental biologylcsh:Biology (General)lcsh:QD1-999enterocytesintestinal epithelial cellsSignal transductionpermeabilitySignal Transductiondescription
Tight junctions play a major role in maintaining the integrity and impermeability of the intestinal barrier. As such, they act as an ideal target for pathogens to promote their translocation through the intestinal mucosa and invade their host. Different strategies are used by pathogens, aimed at directly destabilizing the junctional network or modulating the different signaling pathways involved in the modulation of these junctions. After a brief presentation of the organization and modulation of tight junctions, we provide the state of the art of the molecular mechanisms leading to permeability breakdown of the gut barrier as a consequence of tight junctions’ attack by pathogens, including bacteria, viruses, fungi, and parasites.
year | journal | country | edition | language |
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2021-03-01 | International Journal of Molecular Sciences |