6533b86ffe1ef96bd12cd4ae
RESEARCH PRODUCT
Surveillance of human astrovirus circulation in Italy 2002-2005: emergence of lineage 2c strains.
Claudia ColombaValentina RotoloVito MartellaMaria Angela PlatiaGiovanni M. GiammancoS. De Graziasubject
Microbiology (medical)Settore MED/07 - Microbiologia E Microbiologia ClinicaPathologymedicine.medical_specialtyLineage (genetic)Settore MED/17 - Malattie Infettivesequence analysisSequence analysisMolecular Sequence DataPolymorphism Single NucleotideVirusAstrovirusAstrovirusFecesAstroviridae InfectionsGenotypePrevalenceMedicineHumansTypingChildGenotypingPhylogenyMolecular EpidemiologybiologyPhylogenetic treebusiness.industryGeneral Medicinebiology.organism_classificationVirologyAstrovirus gastroenteritis genotyping Italy sequence analysisInfectious DiseasesgenotypingItalyPopulation SurveillanceRNA ViralbusinessgastroenteritisMamastrovirusdescription
AbstractBy screening faecal samples collected over four consecutive years (2002-2005) from hospitalized children with diarrhoea in Palermo, Italy, astroviruses (HAstVs) were detected in 3.95% of the patients. The predominant type circulating was HAstV-1 but, in 2002, only HAstV-2 and -4 were identified. Interestingly, the HAstVs-2 detected appeared to be consistently different in 5′ end of their open reading frame 2 from the previously described subtypes. These novel type 2 strains were included in a new 2c lineage based on the phylogenetic analysis and the presence of nine peculiar substitutions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-03-12 | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases |