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RESEARCH PRODUCT
Electrospinning of Bioactive Wound-Healing Nets
Emad TolbaWerner E. G. M�llerBärbel Diehl-seifertXiaohong WangHeinz C. Schrödersubject
0301 basic medicineintegumentary systemRegeneration (biology)02 engineering and technologyBiology021001 nanoscience & nanotechnologyBiocompatible materialElectrospinningMicrosphere03 medical and health sciences030104 developmental biologyWound dressingHigh surface areaElectrospun fiber0210 nano-technologyWound healingBiomedical engineeringdescription
The availability of appropriate dressings for treatment of wounds, in particular chronic wounds, is a task that still awaits better solutions than provided by currently applied materials. The method of electrospinning enables the fabrication of novel materials for wound dressings due to the high surface area and porosity of the electrospun meshes and the possibility to include bioactive ingredients. Recent results show that the incorporation of biologically active inorganic polyphosphate microparticles and microspheres and synergistically acting retinoids into electrospun polymer fibers yields biocompatible and antibacterial mats for potential dressings with improved wound-healing properties. The underlying principles and the mechanism of these new approaches in the therapy wounds, in particular wounds showing impaired healing, as well as for further applications in skin regeneration/repair, are summarized.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |