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RESEARCH PRODUCT
Antimitochondrial antibody -M2 positive autoimmune hepatitis during standard of care for chronic hepatitis C.
F. MacalusoN. AlessiD. Cabibisubject
Settore MED/12 - GastroenterologiaSettore MED/08 - Anatomia PatologicaAntimitochondrial antibodies autoimmune hepatitis chronic hepatitis Cdescription
The current standard of care (SoC) for chronic hepatitis C, i.e. the combination of a pegylated-interferon (PEG-IFN) with ribavirin (RBV), may activate underlying autoimmune conditions. Particularly, interferon (IFN) has been known to induce or exacerbate autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) in hepatitis C virus patients. We describe a severe, acute-onset antimitochondrial antibody (AMA)-M2 positive AIH appearing during the last weeks of SoC in a woman with chronic hepatitis C and no previous history of autoimmunity, and resolving on protracted steroids. In this context, the relevance of the characterization of the immunoglobulin isotype of portal plasma cells for a more appropriate diagnosis of autoimmune liver diseases can be emphasized.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-04-01 |