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RESEARCH PRODUCT

Transient Neonatal Hypercholesterolemia

U. DimitaMaurizio AvernaC.m. BarbagalloV. ScafidiG. Di PaolaNotarbartolo AF. P. La Placa

subject

medicine.medical_specialtyAdrenal glandbusiness.industryCholesterolEndocrinology Diabetes and Metabolismmedicine.medical_treatmentBiochemistry (medical)Clinical BiochemistryGeneral MedicineBiochemistryPathophysiologychemistry.chemical_compoundSteroid hormoneEndocrinologymedicine.anatomical_structureDehydroepiandrosterone sulfateEndocrinologychemistryInternal medicineCord bloodmedicineNormal cholesterolbusinessHormone

description

In order to obtain new information about the relationship between transient neonatal hypercholesterolemia and adrenal gland function, we have studied 39 healthy babies found hypercholesterolemic at birth and 39 healthy controls with normal cholesterol levels. The results of this study have shown that levels of dehydroepiandrosterone sulfate in cord blood were not significantly different in the hypercholesterolemic subjects compared with normolipidemic controls (1.4 +/- 0.5 micrograms/dl vs 1.3 +/- 0.5 mu/dl). Moreover correlations between this hormone and levels of total and LDL-cholesterol were not only not statistically significant but even positive (respectively r = +0.207 and +0.195). These data suggest that dehydroepiandrosterone sulfate measurements in cord blood do not give any further information about transient neonatal hypercholesterolemia.

yearjournalcountryeditionlanguage
1993-05-01Hormone and Metabolic Research
https://doi.org/10.1055/s-2007-1002095