6533b86ffe1ef96bd12ce89c
RESEARCH PRODUCT
Separation of aromatic aminophosphonic acid enantiomers by capillary electrophoresis with the application of cyclodextrins
Piotr WieczorekPaweł KafarskiPaweł KafarskiPaweł DżygielEwa Rudzińskasubject
chemistry.chemical_classificationcyclodextrinsChromatographyaminophosphonic acidsCyclodextrinHydrogen bondOrganic ChemistryOrganophosphonatesElectrophoresis CapillaryStereoisomerismorganophosphorus compoundsGeneral MedicineElectrolyteBiochemistryAnalytical ChemistryHydrophobic effectCapillary electrophoresischemistryAminophosphonatePhase compositionpolycyclic compoundsEnantiomerdescription
The detailed studies concerning capillary electrophoresis separation of aminophosphonic acid enantiomers with various commercially available cyclodextrins are presented. The obtained results show that the separation of these stereoisomers is dependent on pH of background electrolyte, concentration of cyclodextrin as well as on the type of applied chiral selector. The separation mechanism is based on the co-operative effect of hydrogen bond type interactions enhanced by hydrophobic forces and sterical constrains between aminophosphonate and cyclodextrin. With application of elaborated method, enantiomeric baseline or partial separation of 18 alpha-aminophosphonic acids was achieved. This separation can be successfully used for routine aminophosphonic acids enantiopurity determination.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-12-01 | Journal of Chromatography A |