6533b86ffe1ef96bd12ce8e2

RESEARCH PRODUCT

Synthesis of Multisubstituted 1,4-Dihydrobenzoxazin-2-ones through a One-Pot Nucleophilic N-Alkylation/C-Alkylation of Cyclic α-Imino Esters

Lode De MunckCarlos VilaCarolina PonsJosé R. Pedro

subject

Carbon atom010405 organic chemistryChemistryOrganic Chemistrychemistry.chemical_elementZincAlkylation010402 general chemistry01 natural sciencesCatalysis0104 chemical sciencesUmpolungReaccions químiquesCompostos orgànics SíntesiNucleophileOne pot reactionReagentOrganic chemistrylipids (amino acids peptides and proteins)Química orgànica

description

A nucleophilic N-alkylation of 2-oxobenzoxazine-2-carboxylates with organozinc reagents with good selectivities and in moderate to good yields is described. Moreover, the synthesis of multisubstituted 1,4-dihydrobenzoxazine-2-ones bearing a tetrasubstituted carbon atom via a one-pot N-alkylation/C-alkylation reactions is reported.

yearjournalcountryeditionlanguage
2017-03-09
10.1055/s-0036-1588742https://doi.org/10.1055/s-0036-1588742